Synthesis and Pharmacological Characterization of Certain Baclofen Analogues
نویسندگان
چکیده
MOHAMED I. ATTIA, CLAUS HERDEIS, HANS BRÄUNER-OSBORNE Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia Department of Pharmaceutical Chemistry, Institute of Pharmacy and Food Chemistry, Würzburg University, Am Hubland, 97074, Würzburg, Germany Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
منابع مشابه
A facile and efficient synthesis of Baclofen
γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesize...
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متن کاملSynthesis of Baclofen; an Alternative Approach
g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...
متن کاملSynthesis of Baclofen; an Alternative Approach
g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...
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تاریخ انتشار 2013